<i>In vitro</i> activity of hyperthermia on swarming motility and antimicrobial susceptibility profiles of <i>Proteus mirabilis</i> isolates

Aim Swarming motility is a virulence factor for Proteus mirabilis and coordinated multicellular movement of bacteria. In this study, we investigated the inhibitory effect hyperthermia on bacterial swarming antimicrobial resistance.Methods Thirty-one P. isolates were included in study. Seven inoculated agar plates incubated inside incubators with increasing temperature levels: at 36 °C (control) 40–45 °C. On next day, inhibition was evaluated minimum paralyzing (MPT) values determined. An susceptibility test (antibiogram) performed by exposing bacteria to concentrations antibiotics, vitro. Thus, used Kirby-Bauer disk diffusion as screening method analyze antibiogram profiles 42 Finally, time-kill assay killing (42 °C) planktonic bacteria, combination antibiotic meropenem first third hours. A Wilcoxon signed-rank compare effects meropenem, their combinations.Results The median MPT value determined 44 assay, development observed 94% least one antibiotic. significant meropenem. Under microscope, formation spherical cells heat.Conclusion We conclude that these findings might be useful when employing treat infectious diseases caused future.